Incomplete base excision repair contributes to cell death from antibiotics and other stresses
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چکیده
منابع مشابه
The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death.
DNA-alkylating agents have a central role in the curative therapy of many human tumors; yet, resistance to these agents limits their effectiveness. The efficacy of the alkylating agent temozolomide has been attributed to the induction of O6-MeG, a DNA lesion repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT). Resistance to temozolomide has been ascribed to elevated levels of ...
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Base excision repair (BER) protein expression is important for resistance to DNA damage-induced cytotoxicity. Conversely, BER imbalance [DNA polymerase beta (Polbeta) deficiency or repair inhibition] enhances cytotoxicity of radiation and chemotherapeutic DNA-damaging agents. Whereas inhibition of critical steps in the BER pathway result in the accumulation of cytotoxic DNA double-strand breaks...
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Currently five polymerases have been identified in Escherichia coli, at least eight in Saccharo‐ myces cerevisiae, nine in Schizosaccharomyces pombe, and fourteen in humans [1-4]. Based on the primary structure of the catalytic subunits, DNA polymerases have been classified into different families. Eukaryotic organisms have four families: A family (Polγ, Polθ and Polν), B family (Polα, Polδ, Po...
متن کاملBase excision DNA repair and cancer
Transformed cells can develop drug resistance via repair mechanisms that counteract the DNA damage from chemotherapy or radiation therapy. Disruption of DNA repair pathways can cause mis-repair that is cytotoxic [1]. Specific DNA repair inhibitors might thus be combined with DNA-damaging agents for improved therapy. In addition, some cancer cells have a reduced repertoire of DNA damage response...
متن کاملBase excision and nucleotide excision repair pathways in mycobacteria.
About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount significance for its survival within the host. ...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2018
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2018.08.014